Electromagnetic radiation at 835 MHz changes the morphology and inhibits proliferation of a human astrocytoma cell line.

French PW, Donnellan M, McKenzie DR

Bioelectrochem Bioenerg 43:13-18, 1997

A human astrocytoma cell line, U-87 MG, was exposed to 835 MHz electromagnetic radiation for 20 min, 3 times per day for 7 days, at a power density of either 40+15 mW/cm² or 8.1 + 3 mW/cm².

At the low power density, it was observed that the rate of DNA synthesis decreased, and that the cells flattened and spread out in comparison to unexposed culture. At 40 mW/cm², there were no effects seen on cell proliferation, but alteration in cell morphology included increased cell spreading and also the appearance of actin-containing blebs at localized sites on the membrane. It is hypothesised that 835 MHz radiation at low power density may be affecting a signal transduction pathway involved in cell proliferation.